New York took two out of three from Boston after losing the first eight meetings to the Red Sox last season. Chan Ho Park (1-1) pitched three scoreless innings for the win while Papelbon (0-1) suffered the loss.
Granderson greeted Papelbon in the tenth inning with a home run into the right field bleachers. It was his second home run in three games after hitting a round-tripper in his first Yankee at-bat on Sunday.
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